It's pretty rare for me to sit and watch ANYTHING by myself, and actually laugh at it. More than just a "hah," or a small response to some joke.
This show is HILARIOUS.
I know everyone might have at least HEARD of Family Guy, maybe watched a few episodes, but I honestly think that if you can sit and watch an entire episode without laughing at all, you need to make a doctor's appointment.
The show catches you off guard so often, and I think that's one of its best elements. Take this for example. Peter Griffin's son, Chris, is being bullied by a kid at school. Peter, being the great father that he is, goes over to the child's house to have a discussion with him about the situation.